Calculate your due date

This article was written by Rebecca Dekker, PhD, RN, APRN
Published April 15, 2015, © Evidence Based Birth®, All Rights Reserved.

What is an estimated due date, and how is it determined?

What are the risks of going past your due date? Does induction increase the risk of C-section? At which point do the benefits of being electively induced outweigh the risks? Do women’s goals and preferences for their births matter?

The purpose of this Evidence Based Birth® article is to look at the evidence on due dates.

How often are women induced for going past their estimated “due date?”

Inductions for non-medical reasons have been on the rise in the U.S. Increasingly, more women are being induced because they have reached their estimated “due date” of 40 weeks. According to the 2013 Listening to Mothers III survey, more than four out of ten mothers (41%) in the U.S. said that their care provider tried to induce labor (Declercq et al. 2014). The researchers asked women to select the reasons that they were induced. What was the single most common reason for labor induction? Out of all women who were induced, 44% said that they were induced because their baby was full term and it was “close to the due date.” Another 18% said that they were induced because the health care provider was concerned that the mother was “overdue.”

Why is there so much controversy about elective induction?

For many years, the common belief was that elective (not medically indicated) inductions doubled the C-section rate, especially in first-time mothers. Elective inductions might occur for social reasons, like the doctor wanting the mom to give birth before he or she goes out of town, or other non-medical reasons like the mother wanting to be done with an uncomfortable pregnancy. However, in the 2010s, some researchers began to dispute the claim that elective induction doubles the risk of cesarean. They argued that earlier studies—where elective induction showed a doubling in C-section rates—were flawed. In the earlier studies, elective induction was compared only to spontaneous labor: women who were electively induced vs. women who went into spontaneous labor.  Excluded from these two groups are women who were not electively induced, but chose to wait for labor and then ended up having medically indicated inductions later on (and, thus, a higher rate of C-sections). For an example of this earlier flawed research, see this article by Yeast et al. 1999.

image-3New researchers pointed out that we need to compare women who have elective inductions with the whole group of women who choose to wait for spontaneous labor—whether or not they actually do have spontaneous labor. This is a subtle difference, but an important one, because not all women who choose to wait will actually have a spontaneous labor; some of them will develop complications that lead to an induction and increase their risk for C-section.  The researchers argued that the comparison group must include that group of women. This graphic shows how you would look at the two groups: the elective induction group vs. the entire group of women who were not electively induced—some of whom would, in fact, end up being induced later for medical reasons.

image-1Because of this flaw in the earlier studies, the researchers argued, we really can’t determine if elective induction between 39-41 weeks is better or worse than waiting for labor to start on its own (see this PowerPoint by Dr. Robert Silver for more information).

Enter the ARRIVE study.

Funded by the U.S. National Institutes of Health, the doctors in charge of the ARRIVE study (A Randomized Trial of Induction Versus Expectant Management) are currently enrolling 6,000 first-time moms from across the U.S. These women are being randomly assigned to elective induction at 39 weeks OR waiting for labor to start on its own (expectant management), up until 41 weeks. According to the informed consent document for the study, “The goal of the study is to find out whether coming to the hospital and having your labor started with medicine (induced) at 39 weeks of pregnancy can improve the baby’s health at birth when compared with waiting for labor to start on its own.

Vanessa was planning on another natural birth with her 3rd child. At 39 weeks she elected for an induction due to severe, chronic sciatica pain. She was surprised by the intensity of the Pitocin-induced contractions, and needed an epidural. Vanessa ended up with an emergency Cesarean when her baby (who was moving constantly during the intense contractions) flipped breech/ transverse during the induction.
Vanessa was planning on another natural birth with her 3rd child. At 39 weeks she elected for an induction due to severe, chronic sciatica pain. She was surprised by the intensity of the Pitocin-induced contractions, and needed an epidural. Vanessa ended up with an emergency Cesarean when her baby (who was moving constantly during the intense contractions) flipped breech/ transverse during the induction.

The study brochure (used to recruit women into the study) says that “During labor induction, the same types of complications that can arise during spontaneous labor can occur.” Unfortunately, this statement is not quite true, because risks of inductions include hyper-stimulation of the uterus (where the uterus contracts too frequently, decreasing blood flow to the baby), the use of extra interventions such as continuous fetal monitoring and the need for additional pain relief, and a failed induction leading to a Cesarean (NICE Guidelines, 2008). Although the researchers are looking at the benefits and risks of elective induction at 39 weeks—including Cesarean rates, serious infant health problems, hospital costs, and patient satisfaction—they are not looking at the bigger implications of their goal. Their goal is to find out that when all women give birth by 39 weeks, there are better outcomes than letting women wait for spontaneous labor. But since only 10% of women go into labor on their own by 39 weeks (Smith 2001; Jukic et al. 2013), what would happen if labor and delivery units all over the world were filled with women having elective inductions at 39 weeks? Would there be any unintended effects? What might happen to a woman who has a serious medical need for an induction, but can’t get on the schedule because all of the hospital beds are full of women being electively induced at 39 weeks?  Some people may argue that this elective induction epidemic is already happening… so we need research in order to learn the pros and cons of elective induction at 39 weeks! However, one thing that the ARRIVE study won’t tell us is whether or not induction at 39 weeks can decrease the risk of stillbirth or newborn death. In earlier research, it took a sample size of at least 7,000 women to tell whether elective induction at 41-42 weeks decreases the combined risk of stillbirth and newborn death (Hussain et al. 2011; Gulmezoglu et al. 2012). Since stillbirths and newborn deaths are even rarer at 39 and 40 weeks, the ARRIVE study (with 6,000 women) is simply too small to tell if elective induction will have an effect on this outcome.

What does it mean to be “full term?”

For many years, a baby was defined as being born at “term” if it was born between 37 weeks 0 days and 41 weeks 6 days. Anything before that 5-week period was considered “preterm,” and anything after those five weeks was “post-term. Over time, though, research began to show that health problems were more common at certain points during this 5-week “term” period. In particular, newborns are more likely to die (although the overall risk was still very low) if they are born before 39 weeks, or after 41 weeks. The chance of a newborn having problems is lowest if he or she is born between 39 weeks and 0 days and 40 weeks and 6 days (Spong 2013). In 2012, a group of experts came together to define “term” pregnancy. Based on their review of the research evidence, they broke the 5-week term period into separate groups (Spong 2013)

  • “Early term” babies are born between 37 weeks 0 days and 38 weeks 6 days
  • “Full term” babies are born between 39 weeks 0 days and 40 weeks 6 days.
  • “Late term” babies are born between 41 weeks 0 days and 41 weeks 6 days
  • “Post term” babies are born at 42 weeks and 0 days or later

How do you figure out your estimated due date?

Almost everyone—including doctors, midwives, and online due date calculators—uses Naegele’s rule (listen to the pronunciation here) to figure out an estimated due date (EDD). Naegele’s rule assumes that you had a 28-day menstrual cycle, and that you ovulated exactly on the 14th day of your cycle (Note: some health care providers will adjust your due date for longer or shorter menstrual cycles). To calculate your EDD according to Naegele’s rule, you add 7 days to the first day of your last period, and then count forward 9 months (or count backwards 3 months). For example, if your last menstrual period was on April 4, 2015, you would add seven days (April 11, 2015) and subtract 3 months = an estimated due date of January 11, 2016. Another way to look at it is to say that your EDD is 40 weeks after the first day of your last period.

But where did Naegele’s rule come from?

In 1744, a professor from the Netherlands named Hermann Boerhaave explained how to calculate an estimated due date. Based on the records of 100 pregnant women, Boerhaave figured out the estimated due date by adding 7 days to the last period, and then adding nine months (Baskett & Nagele 2000). However, Boerhaave never explained whether you should add 7 days to the beginning of the last period, or to the last day of the last period. In 1812, a professor from Germany named Carl Naegele quoted Professor Boerhaave, and added some of his own thoughts. (This is how Naegele’s rule got its name!)

However, Naegele, like Boerhaave, did not say when you should start counting—from the beginning of the last period, or the last day of the last period. His text can be interpreted one of two ways: either you add 7 days to the first day of the last period, or you add 7 days to the last day of the last period.

As the 1800s went on, different doctors interpreted Naegele’s rule in different ways. Most added 7 days to the last day of the last period. However, by the 1900s, for some unknown reason, American textbooks adopted a form of Naegele’s rule that added 7 days to the first day of the last period (Baskett & Nagele 2000).

And so this brings us to today, where almost all doctors use a form of Naegele’s rule that adds 7 days to the first day of your last period, and then counts forward 9 months—a rule that is not based on any current evidence, and may not have even been intended by Naegele.

Inspired by this blog article, we created these really cute buttons… click on the image to find out how you can get yours!

What is the most accurate way to tell how far along you are?

Doctors started using ultrasound in the 1970s. Soon after, ultrasound measurement replaced last menstrual period (LMP) as the most reliable way to define gestational age (Morken et al. 2014). A large body of evidence shows that ultrasounds done in early pregnancy are more accurate than using LMP to date a pregnancy. In a 2010 Cochrane review, researchers combined the results from 7 randomized clinical trials that compared routine early ultrasound to a policy of not routinely offering ultrasound. The researchers found that women who had an early ultrasound to date the pregnancy were less likely to be induced for a post-term pregnancy. In other words, using the LMP to estimate your due date makes it more likely that you will be mislabeled as “post-term” and experience an unnecessary induction. In a large observational study that enrolled more than 17,000 women in Finland, researchers found that ultrasound at any time point between 8 and 16 weeks was more accurate than the LMP. When ultrasound was used instead of a “certain” LMP (in other words, the mother is “certain” about the date she had her last period), the number of “post-term” pregnancies decreased from 10.3% to 2.7% (Taipale & Hiilesmaa 2001).

Why is LMP less accurate than using ultrasound?

There are several reasons why the LMP is usually less accurate than an ultrasound (Savitz et al. 2002; Jukic et al. 2013; ACOG 2014). LMP is less accurate because it can have these problems:

  • Women can have irregular menstrual cycles, or cycles that are not 28 days
  • Women may be uncertain about the date of their LMP
  • Many women do not ovulate on the 14th day of their cycle
  • The embryo may take longer to implant in the uterus for some women
  • Research indicates that some people are more likely to recall a date that includes the number 5, or even numbers, so they may inaccurately recall that the first day of their LMP has one of these numbers in it

What is the best time to have an ultrasound to determine gestational age?

In a recent study, researchers grouped ultrasound scans by <7 weeks, 7-10 weeks, 11-14 weeks, 14-19 weeks, and 20-27 weeks (Khambalia et al. 2013). The authors found that the most accurate time to perform an ultrasound to determine the gestational age was 11-14 weeks. About 68% of women gave birth ±11 days of their estimated due date as calculated by ultrasound at 11-14 weeks. This was a more accurate result than any of the other ultrasound scans, and more accurate than the LMP. The accuracy of the ultrasound saw a significant decline starting at about 20 weeks. Using an estimated due date from either the LMP or an ultrasound at 20-27 weeks led to a higher rate of pre- and post-term births.

Should a due date be changed based on a third trimester ultrasound?

In the Listening to Mothers III study, one in four women (26%) reported that their care provider changed their estimated due date based on a late pregnancy ultrasound. For 66% of the women, the estimated due date was moved up to an earlier date, while for 34% of women the date was moved back to a later date (Declercq et al. 2014).

Ultrasounds in the third trimester are less accurate than earlier ultrasounds or the LMP at predicting gestational age. Ultrasounds in the third trimester are not as accurate because they are measuring the size of the baby and comparing him or her to a “standard” sized baby. All babies are about the same size early in pregnancy. But if your baby will be larger than average, it will be perceived as “closer to done” when the ultrasound is done, and your due date will be moved up (incorrectly). The reverse is also true for babies that will be smaller than average at term—their due date might be moved to a later date. This could be risky if the baby is experiencing growth restriction, as growth-restricted babies have a higher risk of stillbirth towards the end of pregnancy.

Because of these problems with third trimester ultrasounds, the American College of Obstetricians and Gynecologists states that due dates should only be changed in the third trimester in very rare circumstances (2014). They suggest that the due date should only be changed after a third trimester pregnancy ultrasound if 1) it is the woman’s first ultrasound, and 2) it is more than 21 days different than the due date suggested by the LMP (ACOG 2014).

How long is a normal pregnancy? Is it really 40 weeks?

In the U.S. and other Western countries, induction is common at or even before 40 weeks, so it is impossible to know exactly what percentage of women today would naturally go into labor and give birth before, on, or after their estimated due date. In the past, researchers figured out the average length of a normal pregnancy by looking at a large group of women, and measuring the time from ovulation (or the last menstrual period, or an ultrasound) until the date the women gave birth—and calculating the average. However, this method is wrong and does not give us accurate results.

Alicia, a certified doula, birthed her second daughter exactly on her EDD. At her 40 week appointment with her OB she was informed that she was two centimeters dilated and they talked about waiting for induction until 42 weeks. That same afternoon labor began! Her daughter was born the next morning. She described her birth as “a beautiful, happy, identity-changing, empowering experience”.
Alicia, a certified doula, birthed her second daughter exactly on her EDD. At her 40 week appointment with her OB she was informed that she was two centimeters dilated and they talked about waiting for induction until 42 weeks. That same afternoon labor began! Her daughter was born the next morning. She described her birth as “a beautiful, happy, identity-changing, empowering experience”.

Why is this method wrong?

This method does not work because many women are induced when they reach 39, 40, 41, or 42 weeks. If you do include these induced women in your average, then you are including women who gave birth earlier than they would have otherwise, because they were not given time to go into labor on their own. But this puts researchers in a bind, because if you exclude a woman who was induced at 42 weeks from your study, then you are ignoring a pregnancy that was induced because she went longer—and by excluding her, you artificially make the average length of pregnancy too short.

So how can we deal with this problem?

Researchers today use a method called “survival analysis” or “time to event analysis.” This is a special method that allows you to include all of these women in your study, and still get an accurate picture of how long it takes the average woman to go into spontaneous labor. There have been two studies that measured the average length of pregnancy using survival analysis:

Study finds that estimated due date is 3 to 5 days AFTER 40 weeks

In a very important study published in 2001, Smith looked at the length of pregnancy in 1,514 healthy women whose estimated due dates, as calculated by the last menstrual period, were perfect matches with estimated due dates from their first trimester ultrasound (Smith 2001). The researchers found that 50% of all women giving birth for the first time gave birth by 40 weeks and 5 days, while 75% gave birth by 41 weeks and 2 days. Meanwhile, 50% of all women who had given birth at least once before gave birth by 40 weeks and 3 days, while 75% gave birth by 41 weeks. This means that for both first-time and experienced mothers in Smith’s study, the traditional “estimated due date” of 40 weeks was wrong! The actual pregnancy was about 5 days longer than the traditional due date (using Naegele’s rule) in a first-time mother, and 3 days longer than the traditional due date in a mother who has given birth before.

Study finds that estimated due date should be closer to 40 weeks and 5 days

In 2013, Jukic et al. used survival analysis to look at the normal length of a pregnancy. This was a smaller study—there were only 125 healthy women enrolled, and they all gave birth between the years 1982 and 1985. However, this was also an important study, because researchers followed these women before conception and measured their hormones daily for six months (Jukic et al. 2013). This means that the researchers knew the exact days that the women ovulated, conceived, and even when their pregnancies implanted!

Sigrid, a newborn nurse and lactation consultant at a busy urban hospital, was planning a second home birth VBAC with her fourth baby. When she reached 42 weeks, she risked out of a home birth and began planning for a hospital birth. When labor finally started on its own at 43 weeks, her baby was born too quickly to make it to the hospital, and she ended up with an accidental unassisted home birth after Cesarean. Sigrid said that her daughter “took FOREVER to decide to be born, but when she wanted out, she meant business!“
Sigrid, a newborn nurse and lactation consultant at a busy urban hospital, was planning a second home birth VBAC with her fourth baby. When she reached 42 weeks, she risked out of a home birth and began planning for a hospital birth. When labor finally started on its own at 43 weeks, her baby was born too quickly to make it to the hospital, and she ended up with an accidental unassisted home birth after Cesarean. Sigrid said that her daughter “took FOREVER to decide to be born, but when she wanted out, she meant business!“

So what was the average length of a pregnancy in this study?

After excluding women who had preterm births or pregnancy-related medical conditions, the final sample of 113 women had a median time from ovulation to birth of 268 days (38 weeks, 2 days after ovulation). The median time from the first day of the last menstrual period to birth was 285 days (or 40 weeks, 5 days after the last menstrual period). The length of pregnancy ranged from 36 weeks and 6 days to one woman who gave birth 45 weeks and 6 days after the last menstrual period. The 45 weeks and 6 days sounds really long… but this particular woman actually gave birth 40 weeks and 4 days after ovulation. Her ovulation did not fit the normal pattern, so we know her LMP due date was not accurate. The researchers also found that:

  • 10% gave birth by 38 weeks and 5 days after the LMP
  • 25% gave birth by 39 weeks and 5 days after the LMP
  • 50% gave birth by 40 weeks and 5 days after the LMP
  • 75% gave birth by 41 weeks and 2 days after the LMP
  • 90% gave birth by 44 weeks and zero days after the LMP

Remember though, some of these women did not ovulate on the 14th day of their period (that’s why you saw the statistic that 10% still haven’t given birth by 44 weeks after the LMP!) So if we look at when women give birth after ovulation, you’ll see this pattern:

  • 10% gave birth by 36 weeks and 4 days after ovulation
  • 25% gave birth by 37 weeks and 3 days after ovulation
  • 50% gave birth by 38 weeks and 2 days after ovulation
  • 75% gave birth by 39 weeks and 2 days after ovulation
  • 90% gave birth by 40 weeks and zero days after ovulation

Women who had embryos that took longer to implant were more likely to have longer pregnancies. Also, women who had a specific sort of hormonal reaction right after getting pregnant (a late rise in progesterone) had a pregnancy that was 12 days shorter, on average.

So is the traditional “due date” really your due date?

Based on best evidence, there is no such thing as an exact “due date,” and the estimated due date of 40 weeks is not accurate. Instead, it would be more appropriate to say that there is a normal range of time in which most women give birth. About half of all women will go into labor on their own by 40 weeks and 5 days (for first-time mothers) or 40 weeks and 3 days (for mothers who have given birth before). The other half will not. If women are worried about experiencing pressure from their friends to give birth by a certain time point, they may want to tell family and friends that they have a “guess date” or a “guess month,” and refrain from sharing any specific estimated due date.

Inspired by this blog article, we created these really cute buttons... click on the image to find out how you can get yours!
Inspired by this blog article, we created these really cute buttons. You can also turn them into Facebook profile pics! Click on the image to find out how you can get yours!

Are there some things that can make your pregnancy longer?

By far, the most important predictor of a longer pregnancy is a family history of long pregnancies—including your own personal history, your mother and sisters’ history, and your male partner’s family history (Jukic et al. 2013; Oberg et al. 2013; Mogren et al. 1999; Olesen, et al. 1999; Olesen et al. 2003)

In 2013, Oberg et al. published a large study that looked at more than 475,000 Swedish births, most of which were dated with an ultrasound before 20 weeks. They found that genetics had an incredibly strong influence on your chance of having a birth after 42 weeks:

  • If you’ve had a post-term birth before, you have 4.4 times the chance of having another post-term birth with the same partner
  • If you’ve had a post-term birth before, and then you switch partners, you have 3.4 times the chance of having another post-term birth with your new partner
  • If your sister had a post-term birth, you have 1.8 times the chance of having a post-term birth

Overall, researchers found that half of your chance for having a post-term birth comes from genes. This includes the baby’s genetic tendency to gestate longer (due to genes the baby inherited from the mother and the father), and the mother’s genetic tendency to carry a pregnancy longer. The Swedish researchers even proposed that you could call some pregnancies “resistant,” because these women and/or fetuses have a genetically decreased tendency to start labor. Other factors that may make your pregnancy more likely to go longer include:

With her first pregnancy, Shannon did not go into labor on her own by 42 weeks, and so she was induced with Cytotec. Her drug-induced contractions were very intense– she had contractions that lasted 60-90 seconds every 1 and a half minutes for 10 hours. Shannon gave birth vaginally to a healthy 7 lb, 8 oz baby, although there was some meconium aspiration. Two years later, Shannon gave birth again spontaneously at 41 weeks and 2 days (after membrane stripping), and her sister had a post-term pregnancy and went into labor spontaneously at 42 weeks 5 days. 
With her first pregnancy, Shannon did not go into labor on her own by 42 weeks, and so she was induced with Cytotec. Her drug-induced contractions were very intense– she had contractions that lasted 60-90 seconds every 1 and a half minutes for 10 hours. Shannon gave birth vaginally to a healthy 7 lb, 8 oz baby, although there was some meconium aspiration. Two years later, Shannon gave birth again spontaneously at 41 weeks and 2 days (after membrane stripping), and her sister had a post-term pregnancy and went into labor spontaneously at 42 weeks 5 days.

What are the risks of going past your due date?

The risks of some complications go up as you go past your due date, and there are three recent studies that have shown us what the risks are.

  1. In 2003, Caughey et al. looked at 135,560 women who gave birth at term in California between the years 1995 and 1999 (Caughey et al. 2003). The women in this sample all gave birth at Kaiser Permanente hospitals in northern California. The overall use of interventions (C-sections and inductions) in this sample was not listed.
  1. In 2004, Caughey et al. looked at the records of 45,673 women who gave birth in a single hospital in California from 1992 to 2002 (Caughey & Musci 2004). The women in this study were mostly well-educated. As far as intervention rates go, 18% gave birth by Cesarean and 16% with the help of vacuum or forceps. The rate of inductions was not listed.
  1. In 2007, Caughey et al. studied the medical records of 119,254 women who gave birth after 37 weeks at Kaiser Permanente between the years of 1995 and 1999. This was the same time period and same hospital as his 2003 study, but this time the researchers only looked at low-risk women who had health insurance. The overall C-section rate was 13.8%, and 9.3% gave birth with the help of vacuum or forceps. The authors also took whether or not women had inductions into account when they calculated the risks of going past your due date (Caughey 2007).

Risks for mothers:

  • The risk of chorioamnionitis (infection of the membranes) was lowest at 37 weeks (0.16%) and increased every week after that to a high of 6.15% at ≥ 42 weeks (Caughey et al. 2003)
  • The risk of endomyometritis (infection of the uterus) was lowest at 38 weeks (0.64%) and increased every week after that to a high of 2.2% at ≥ 42 weeks (Caughey & Musci 2004)
  • The risk of having a placenta abruption (placenta separates prematurely from the uterus) was lowest at 37 weeks (0.09%), and increased every week to a high of 0.44% at ≥ 42 weeks (Caughey et al. 2003)
  • The risk of preeclampsia was lowest at 37 weeks (0.4%) and highest at 40 weeks (1.5%), after which the risk did not change (Caughey et al. 2003)
  • The risk of postpartum hemorrhage was lowest at 37 weeks (1.1%) and increased almost every week to a high of 5% at 42 weeks (Caughey 2007)
  • The risk of a primary Cesarean (in women who have never had a Cesarean before) increased from 14.2% at 39 weeks to a high of 25% at ≥42 weeks (Caughey & Musci 2004)
  • The risk of having a primary Cesarean for a non-reassuring fetal heart rate was lowest at 37-39 weeks (13.3-14.5%) and reached a high of 27.5% at 42 weeks (Caughey 2007)
  • The risk of needing forceps or vacuum assistance increased from 14.1% at 38 weeks to a high of 18.5% at 41 weeks (Caughey & Musci 2004)
  • The risk of having a 3rd or 4th degree tear was lowest at 37 weeks (3.4%) and increased every week to a high of 9.1% at 42 weeks. However, these numbers are much higher than are typically seen, and are partially related to the high use of vacuum and forceps in this study.
Rebecca went in to labor at 41 weeks expecting a home birth, but soon after labor began she noticed that her blood pressure was high and she had a headache. Rebecca went to the hospital with her midwife to be evaluated, and found that she had developed severe preeclampsia with neurological involvement. Rebecca agreed to Pitocin, an epidural, and magnesium. She gave birth vaginally to her son at the hospital.
Rebecca went in to labor at 41 weeks expecting a home birth, but soon after labor began she noticed that her blood pressure was high and she had a headache. Rebecca went to the hospital with her midwife to be evaluated, and found that she had developed severe preeclampsia with neurological involvement. Rebecca agreed to Pitocin, an epidural, and magnesium. She gave birth vaginally to her son at the hospital.

In their 2007 study, Caughey et al. reported that high use of induction, Cesareans, and vacuum/forceps for women with increasing gestational age may contribute to an increase in maternal risks. However, when the researchers used a statistical method to control for the use of interventions, the risks still increased with gestational age.

Risks for babies:

  • The risk of moderate or thick meconium increased every week starting at 38 weeks, and peaked at ≥42 weeks (3% at 37 weeks, 5% at 38 weeks, 8% at 39 weeks, 13% at 40 weeks, 17% at 41 weeks, and 18% at >42 weeks) (Caughey & Musci 2004)
  • Neonatal intensive care unit (NICU) admission rates were lowest at 39 weeks (3.9%) and rose to 5% at 40 weeks and 7.2% at ≥42 weeks (Caughey & Musci 2004)
  • The risk of the baby being large at birth (>9 lbs 15 oz or >4500 grams) rose starting at 38 weeks (0.5%), and doubled every week after that up until 42 weeks (6%) (Caughey & Musci 2004)
  • The odds of having a low 5-minute Apgar score went up starting at 40 weeks and increased each week until ≥42 weeks (exact numbers not reported; Caughey & Musci 2004)

Other risks for post-term pregnancy include having low fluid, and something called dysmaturity syndrome (growth restriction plus muscle wasting), which happens in about 10% of babies who go past 42 weeks. For more information about meconium, see this article by Midwife Thinking about meconium stained waters.

What about the risk of stillbirth?

In this section, we will talk about how the risk of stillbirth increases towards the end of pregnancy. There are two very important things for you to understand when learning about stillbirth rates in post-term pregnancies. First, there is a difference between absolute risk and relative risk. Absolute risk is the actual risk of something happening to you. For example, if the absolute risk of having a stillbirth at 41 weeks was 0.4 out of 1,000, then that means that 0.4 women out of 1,000 (or 4 out of 10,000) will experience a stillbirth. Relative risk is the risk of something happening to you in comparison to somebody else. If someone said that the risk of having a stillbirth at 42 weeks compared to 41 weeks is 50% higher, then that sounds like a lot. But the actual (or absolute) risk would still be low—0.6 per 1,000 versus 0.4 per 1,000. Yes—0.6 is 50% higher than 0.4, if you do the math! So, while it is a true statement to say “the risk of stillbirth increases by 50%,” it can be a little misleading if you are not looking at the actual numbers behind it. The second important thing that you need understand is that there are different ways of measuring stillbirth rates. Depending on how the rate is calculated, you can end up with different rates.

How do you measure stillbirth rates?

Up until the 1980s, some researchers thought that the risk of stillbirth past 41-42 weeks was similar to the risk of stillbirth earlier in pregnancy. So, they did not think there was any increase in risk with going past your due date. However, in 1987, a researcher named Dr. Yudkin published a paper introducing a new way to measure stillbirth rates. Dr. Yudkin said that earlier researchers used the wrong math when they calculated stillbirth rates—they used the wrong denominator! (Yudkin, Wood et al. 1987)

image-5

Here’s why this formula is wrong: We don’t need to know how many stillbirths happen out of every 1,000 births at 41 weeks. Instead, we need to know how many stillbirths happen at 41 weeks compared to all pregnancies and births at 41 weeks. In other words, you have to include the healthy, living babies that have not been born yet in your denominator.

image-4

When researchers began using this new formula to figure out stillbirth rates, they found something very surprising—the risk of stillbirth decreased throughout pregnancy, until it reached a low point at 37-38 weeks, after which the risk started to rise again. This finding—that the risk of stillbirth decreases throughout pregnancy, and then increases sometime after 37-38 weeks—has been found many times by different researchers in different countries. This phenomenon is called the “U-shaped curve” of stillbirth. In other words, there are higher rates of stillbirth earlier in pregnancy, then they go down around 37-38 weeks, after which they rise again. Because the risk of stillbirth starts to go up even more at 40, 41, and 42 weeks, some researchers argue that although 40 weeks and 3-5 days may be the physiological length of pregnancy, 40 weeks may be the functional length of a pregnancy. In other words, the average pregnancy normally lasts about 40 weeks and 5 days, but in some researchers’ opinion, because of the increased risk of stillbirth and newborn death; 40 weeks may be as long as a pregnancy should go. And although the stillbirth rates may seem really low overall, if you happen to be a parent who experiences the 1 in 1,000 event at 42 weeks, then the risk doesn’t seem so low anymore.

Actual stillbirth rates vs. open-ended stillbirth rates

Even after researchers began using the new way of calculating stillbirth rates, there was still controversy about the best way to calculate this new formula for measuring stillbirth rates. Different than what Yudkin proposed in 1987, some researchers preferred an “open-ended” stillbirth rate (also known as the “prospective risk of stillbirth”). An open-ended stillbirth rate at 40 weeks would tell us what a woman’s risk of stillbirth was for any time after 40 weeks, if she let the pregnancy continue indefinitely. Other researchers argued that most women (and doctors!) don’t want to know what the risk of stillbirth would be if a woman chose to let the pregnancy continue on and on! (Hilder et al. 2000). They just want to know what the risk would be if they waited one more week until the next appointment, or even a few days. But the “open-ended” stillbirth rate tells you what your risk of stillbirth at 40 weeks would be if you include babies born not just at 40 weeks, but 41 weeks, 42 weeks, 43 weeks, and on! (Boulvain et al. 2000). In the end, you will find that stillbirth rates vary from study to study, depending on whether the researchers report the actual stillbirth rate, or the open-ended stillbirth rate.

So what is the risk of stillbirth as you go past your due date?

Since the late 1980’s, there have been at least 12 large studies that looked at the risk of stillbirth during each week of pregnancy. Some of the researchers used open-ended stillbirth rates, and some of them used actual stillbirth rates. All of the researchers found a relative increase in the risk of stillbirth as pregnancy advanced. To get an accurate picture of stillbirth in women who go past their due date, it would be best to look at studies that took place in more recent times. I’ve chosen 3 of the most recent studies to show you from Norway, Germany, and the U.S. To see all of the other studies, click to view the entire table (Table is undergoing final formatting and will be COMING SOON!! Make sure to order the free PDF so that you can receive the table by email) All 3 of these studies used the actual stillbirth rate—not the open-ended stillbirth rate. Two studies used ultrasound to calculate gestational age, and one study used the LMP.

Findings_DueDate_Table1

Although most researchers have found an increase in stillbirth rates in the late term and post term period, the “absolute” increase in risk is small until about 42 weeks, after which it reaches about 1 out of 1,000. Based on their data, Rosenstein et al. (2012) calculated that in order to prevent 1 stillbirth or infant death, there would need to be at least 2,442 women electively induced at 39 weeks. They also estimated that 1,476 women would need to be electively induced at 41 weeks in order to prevent one stillbirth or infant death. This is called the “number needed to treat.” In other research that we are going to talk about later on this article, the number needed to treat was much lower.

Does anything increase the risk of stillbirth in women who are past 41 or 42 weeks?

Researchers have found several factors are related to a higher risk of stillbirth: Post-term babies who are small for gestational age (body weight <10th percentile) have a 6-7 times higher chance of stillbirth and newborn death than post-term babies who are not small for gestational age. Also, small for gestational age babies are often growth restricted at the 18-week ultrasound. So, the gestational age for these babies is often under-estimated. This means that babies who are small for gestational age may be more post-term than we realize they are—increasing their risk while also leaving us unaware of their true gestational age (Morken et al. 2014). Other factors that do not necessarily cause stillbirth but may increase the risk of stillbirth, in general, include:

Of course, parents can still experience the stillbirth of a child even when none of these risk factors are present. As many as a third of all stillbirths that take place before labor have no known cause (Warland & Mitchell 2014). To read more about theories of unexplained stillbirth, read this article here.

Induction versus Waiting for Labor

When a woman gets closer or past her due date, she will often face the question about whether to induce labor or wait for labor to start on its own. Inducing labor is also known as “active management.” Waiting for labor to start on its own, with fetal testing to monitor the baby’s status, is called “expectant management.” Many researchers have tried to compare the risks and benefits of induction versus expectant management for women who get close to or go past their due dates.

Cautions about the Evidence

At 40 weeks, Jenny was required by her midwifery practice to see an OB for a routine “due date” consultation. After a cervical exam that showed she was 1 cm dilated, he sent her to the hospital for fetal testing, which showed baby was not moving as much as they would like. The hospital started to prep her for an induction, but she chose eat lunch and have a repeat test, and the results this time were perfect-- so she went home. At 41 weeks and 1 day, Jenny went into labor on her own, and her baby was born weighing 6 lbs, 5 ounces, and was covered with a bit of vernix.
At 40 weeks, Jenny was required by her midwifery practice to see an OB for a routine “due date” consultation. After a cervical exam that showed she was 1 cm dilated, he sent her to the hospital for fetal testing, which showed baby was not moving as much as they would like. The hospital started to prep her for an induction, but she chose eat lunch and have a repeat test, and the results this time were perfect– so she went home. At 41 weeks and 1 day, Jenny went into labor on her own, and her baby was born weighing 6 lbs, 5 ounces, and was covered with a bit of vernix.

Before we begin discussing the evidence, it is important to note that there are some major drawbacks to the evidence that we have so far on induction versus waiting for labor to start:

  1. Many of the clinical trials were carried out in countries or time periods with low Cesarean rates. Some research results may not apply to hospitals with high Cesarean rates. Does your hospital or care provider have high rates of “failed inductions,” and strict time limits on the length of labor? If so, then this evidence may not apply to you, because induction may be more risky (more likely to lead to a C-section) in your specific hospital!
  2. In these studies, women were randomly assigned to induction or to waiting for labor to start on its own. However, cross-over rates were high. For example, in the Hannah PostTerm trial (the biggest study about induction for post-dates), about a third of women who were assigned to the “expectant management group” were actually induced, while about a third of women who were in the induction group went into labor spontaneously. Most researchers only report the Cesarean rates of the two study groups (those who were assigned to expectant management and active management), but it’s also important for us to look at the Cesarean rates in women who were actually induced or who actually went into spontaneous labor.
  3. In most studies, women in the expectant management group had many fetal tests, some of which may have showed possible signs of distress, and some of which were false positives (Minticoglou & Hall, 2002). This could have led to higher rates of Cesarean section for fetal distress during labor in the expectant management group, especially among those women in the expectant management group who were induced for fetal indications (Woods et al. 2013). Another researcher said, “It may be that the results of our review reflect doctors’ discomfort with delayed delivery in high-risk women that, once they are in labor, manifests as more frequent Cesarean sections: an example of research confirming the biases of the health care community” (Woods et al., 2013, pg. 682).
  4. The induction protocols varied from study to study, and even within studies themselves. For example, in the most influential study of all—the Hannah PostTerm study—women in the induction group first received drugs to ripen the cervix, and then drugs to induce labor. Meanwhile, women in the expectant management group who ended up being induced did NOT have cervical ripening. This put the expectant management group at a disadvantage because many of them had inductions without cervical ripening treatment– increasing their risk for a Cesarean.

Meta-analyses

A meta-analysis is when researchers take multiple randomized trials and combine all the data together into one big “meta” study. There have been at least six meta-analyses in which researchers compared women who were electively induced to women who waited for labor to start on their own (See the Annotated Bibliography). However, only four of these meta-analyses specifically looked at induction for post-dates, as opposed to induction for any reason (Sanchez-Ramos et al. 2003; Wennerholm et al. 2009; Hussain et al. 2011; Gulmezoglu et al. 2012). Each meta-analysis’s results are slightly different, depending on which studies the researchers included in their analysis. It’s important to note that the Hannah PostTerm trial was the biggest randomized trial included in all of these meta-analyses, and the driving factor behind most of the meta-analysis findings (Hannah et al. 1992). Meta-analyses are only as good as the trials that are put into them. Unfortunately, all of the trials that were put into these meta-analyses were of fair or poor quality, with most of them being poor quality. As one meta-analysis author said: “The weaknesses of our conclusions are closely linked with the weaknesses of the individual trials” (Wennerholm et al, 2009, pg. 14). Thus, we have to be cautious with how much weight we give to this poor quality evidence and the conclusions it yields.

So what did they find in the meta-analyses?

Three out of three meta-analyses that looked at C-section rates found that there was a slightly lower Cesarean rate in women who are assigned to labor induction at 41 or 42 weeks, compared to women who are assigned to expectant management. Women in the induction groups also had lower rates of Cesarean for non-reassuring fetal heart rates during labor. The decrease in Cesarean rates was almost exclusively due to the Hannah PostTerm trial. In other words, the Hannah study dominated the meta-analysis findings. Two of the four meta-analyses found that there was a lower risk of perinatal death in the induction group compared to the expectant management group. Overall, there were 13 perinatal deaths in the expectant management group (3 of these were due to congenital abnormalities) and 1 death in the induction group—out of about 7,400 women. The researchers calculated that there would need to be 328 to 410 elective inductions at 41 weeks to prevent 1 perinatal death.

Two other Meta-analyses that have been in the news

In 2013, two separate groups of researchers made headlines when their meta-analyses came out, showing that elective induction in general (not just induction at 41 or 42 weeks) decreases the Cesarean rate (Mishanina et al. 2014; Wood et al. 2014). These meta-analyses suffered from the same weaknesses as the meta-analyses above—including a reliance on the Hannah study results (both the Hannah PostTerm study and the Hannah PROM study), inclusion of studies with many different types of induction (including sex, membrane stripping, etc.) and many indications for induction (such as premature rupture of membranes). In other words, these meta-analyses lumped a ton of very different types of trials into one big data-analysis. This blurs the detailed information that is important for interpreting trial results. Also, you might want to note that in the Mishanina meta-analysis, the use of oxytocin for induction did not decrease the risk of Cesarean, and neither did breaking the waters and oxytocin combined. Cervical ripening as a method of induction decreased the risk of Cesarean, while solely inducing uterine contractions did not. When the results were broken down by parity (whether women had given birth before), neither first-time mothers nor women who had given birth before had a decreased risk of Cesarean with induction. Why the different findings when they broke it down by parity? This is probably because the sample size was too small to look at the results when they broke it down into separate groups.

The Famous Hannah “Post-Term” study

We’ve mentioned it before, but the most important study that has ever been done on inducing for post-dates is the Hannah et al. 1992 Post-Term study. This study was published in the New England Journal of Medicine. Because it was such a large study, the Post-Term study controls most of the findings in all of the meta-analyses listed above.

So, let’s look at what happened in this study

Between the years of 1985 to 1990, a group of researchers enrolled 3,407 low-risk women from six different hospitals in Canada into the Hannah Post-Term study. Women could be included if they had a live, single fetus, and were excluded if they were ≥ 44 weeks, were already 3 or more centimeters dilated, had a previous Cesarean, had pre-labor rupture of membranes, or had a medical reason for induction. The study took place in the six Canadian hospitals between the years 1985 and 1990. At around 41 weeks, women were randomly assigned to either induction of labor or fetal monitoring (expectant management). In the induction group:

  • Labor was induced within four days of entering the study (usually about 4 days after 41 weeks)
  • If the cervix was not ripe (< 3 cm dilated and <50% effaced), and if the fetal heart rate was normal, women were given prostaglandin E2 gel to ripen the cervix.
  • A maximum of 3 doses of gel were given every 6 hours. If this did not induce labor or if the gel was not used, women were given IV oxytocin, had their waters broken, or both. They could not receive oxytocin until at least 12 hours after the last prostaglandin gel dose.

In the monitored (expectant management) group:

  • Women were taught how to do kick counts every day and had nonstress tests 3 times per week.
  • The amniotic fluid level was checked by ultrasound 2-3 times per week.
  • Labor was induced if the nonstress test was nonreactive [today we would call this “minimal variability with no accelerations”] or showed decelerations, if there was low amniotic fluid (deepest pocket <3 cm), if complications developed, or if the mother did not go into labor on her own by 44 weeks.
  • If doctors decided that the baby needed to be born, mothers did not receive cervical ripening—instead, they either had their water broken and/or IV oxytocin, or had a Cesarean without labor.

What did researchers find in the Hannah Post-Term study?

There was quite a bit of cross-over between groups. In the induction group, 66% of women were induced, and 34% went into labor on their own before the induction. In the monitoring group, 33% were induced and 67% went into labor on their own. The findings on C-section rates differ, depending on what numbers you look at. You can look at the two original groups—the women randomly assigned to induction and the women assigned to fetal monitoring—regardless of the cross-over that eventually happened between the groups. Or you can look at the breakdown of what actually happened to the women in the two groups. In other words, what happened to the women who were actually induced or actually went into spontaneous labor?

What happened in the original, randomly assigned groups?

If you look at what happened in the two original groups (random assignment to induction and monitoring groups), the overall C-section rate was lower in the induction group (21.2% vs. 24.5%), even after taking into account whether this was the mother’s first baby, her age, cervical dilation at the time of study entry, and race. There was also a lower rate of C-sections for fetal distress in the induction group vs. the monitoring group (5.7% vs. 8.3%).

Graphic of both groups- NEED TO ADD TO RAINMAKER

But what happened to women who were actually induced or actually went into labor on their own?

So, if you break down those two groups—the induction and fetal monitoring groups—and look at what happened in the women who were actually induced, or who actually went into spontaneous labor, this is what you will see (Hannah et al. 1996):

image-2

So we see two very interesting things here: women who went into spontaneous labor, regardless of which group they were originally assigned, had a C-section rate of only 25.7%. But if women in the monitoring group had an induction, their C-section rate was much higher than all of the other groups—42%! The same pattern holds true when you look at experienced mothers (women who had given birth before):

image

So what do these numbers mean?

The true meaning of the Hannah Post-Term study was hidden by the cross-over that happened between groups. The reported main findings were that a policy of fetal monitoring and expectant management increases the C-section rate. But the true finding is that only the women who were expectantly managed but then had an induction had really high C-section rates. Women who were expectantly managed and went into labor spontaneously did NOT have higher C-section rates. So if a woman is considering expectant management after 41 weeks, one of the benefits is that if she goes into labor on her own, she will have a relatively low risk of Cesarean. But one of the potential risks is that if she ends up having an induction (either because she elects to have one or has a medical reason for one), her risk of a Cesarean with that induction is nearly doubled, from 25.7% to 42%. To read more about the other findings of the Hannah study, as well as all of the other randomized trials that have compared induction to expectant management, you can look at the table we’ve posted here. (Table is undergoing final formatting and will be COMING SOON!! Make sure to order the free PDF so that you can receive the table by email)

What about women who are planning a VBAC?

Only 10% of women who reach term give birth by 39 weeks. Tiffany was planning a VBAC and went into labor on her own at 39 weeks and 2 days. Despite being told by the on-call obstetrician that VBAC was dangerous, Tiffany gave birth to her baby vaginally after 13 hours of labor and only 2 pushes. Afterwards, she said “I felt so strong, like I could achieve anything if I set my mind to it.”
Only 10% of women who reach term give birth by 39 weeks. Tiffany was planning a VBAC and went into labor on her own at 39 weeks and 2 days. Despite being told by the on-call obstetrician that VBAC was dangerous, Tiffany gave birth to her baby vaginally after 13 hours of labor and only 2 pushes. Afterwards, she said “I felt so strong, like I could achieve anything if I set my mind to it.”

Many women who are planning a VBAC are told they must go into labor by 39 weeks (or 40 or 41 weeks) or they will be required to have a repeat Cesarean or induction. Research has shown that only about 10% of women who reach term will give birth by 39 weeks (Smith 2001; Jukic et al. 2013). So, if a hospital or physician mandates repeat Cesareans for women who have not gone into labor by 39 weeks, this means that 90% of women planning a VBAC with that hospital or physician will not be able to have a spontaneous VBAC. Also, some hospitals and providers will not provide inductions with VBACs, which means some women who reach the required deadline will only have one option– repeat Cesarean. There is actually no evidence supporting a hard-stop “must-give-birth-by-39-weeks” rule for women planning a VBAC. In 2015, researchers looked at 12,676 women who were electively induced at 39 weeks for a VBAC, or had expectant management for a VBAC (Palatnik & Grobman 2015). Elective induction at 39 weeks was associated with a higher chance of VBAC compared to expectant management (73.8% vs. 60-62%), but there was also a higher rate of uterine rupture in the elective induction group (1.4% vs. 0.4-0.6%). For women who chose not to be induced, the risk of uterine rupture was fairly steady at 39 weeks (0.5% uterine rupture rate), to 40 weeks (0.6%), to 41 weeks (0.4%). For more information on two older studies that have looked at rupture rates after 39-40 weeks, see this article at VBAC Facts.

Is it safe for a woman to wait for labor to begin on its own, if that is what she prefers? How long is it safe to wait?

As women get closer to 41 weeks, it is appropriate for her and her care provider to discuss the benefits and risks of elective induction and expectant management. Most research articles and guidelines say that because there are benefits and risks to both options, the women’s values, goals, and preferences should play a part in the decision-making process. Ultimately, after receiving accurate, evidence-based information and guidance from her health care provider, women have the right to decide whether they prefer to induce labor, or wait for spontaneous labor with fetal monitoring.

Are there any benefits to going past your due date?

At 42 weeks and 1 day and after she had tried every natural induction method possible (including a Foley catheter), Traci’s risked out of a birth center birth. She was induced in a hospital with Cervidil and Pitocin. Traci tried to cope naturally with the contractions but ended up needing an epidural that caused her blood pressure to plummet and her son to have heart rate problems. She finally gave birth vaginally to her son said “the emotion that came over me was like every "I love you" I've ever heard repeated again all at the same time.”
At 42 weeks and 1 day and after she had tried every natural induction method possible (including a Foley catheter), Traci’s risked out of a birth center birth. She was induced in a hospital with Cervidil and Pitocin. Traci tried to cope naturally with the contractions but ended up needing an epidural that caused her blood pressure to plummet and her son to have heart rate problems. She finally gave birth vaginally to her son said “the emotion that came over me was like every “I love you” I’ve ever heard repeated again all at the same time.”

One of the major benefits of going past your due date and awaiting the spontaneous start of labor is the hormonal benefit of experiencing spontaneous labor. In her book Hormonal Physiology of Childbearing (free full text available here), Dr. Sarah Buckley reviewed the research on the hormonal benefits of spontaneous labor . Based on the available evidence, Dr. Buckley concluded that: “Overall, consistent and coherent evidence from physiologic understandings and human and animal studies finds that that the innate, hormonal physiology of mothers and babies—when promoted, supported, and protected—has significant benefits for both in childbearing, and likely into the future, by optimizing labor and birth, newborn transitions, breastfeeding, maternal adaptations, and maternal-infant attachment” (Executive Summary, page 9). Another benefit of going past your due date and experiencing spontaneous labor is that you can avoid the potential risks of a medical induction, which may include experiencing a failed induction (possibly leading to a Cesarean), uterine hypercontractility (uterine contractions that are too close together and may decrease blood flow to the baby), and adverse effects of other interventions that often occur with an induction, such as epidural anesthesia and continuous fetal monitoring (NICE Guidelines, 2008). Although anecdotally it has been said that later term and post-term babies have an easier time with breastfeeding, I was not able to find any research on that subject.

How should a woman and her care provider talk about the risk of stillbirth?

It can be difficult for health care providers and women to discuss the risk of stillbirth. Research on health care decision-making suggests that one of the best ways to frame the risk of stillbirth is to use the following techniques (Perneger & Agoritsas 2011; Fagerlin et al. 2011).

  1. Present risks in actual or “absolute” numbers (as opposed to relative risk)
  2. Talk about both potential gains and losses
  3. Offer a visual if possible
  4. Focus on the absolute difference between two risks

So, in a real life situation, this might look like: “At 41 weeks, out of 10,000 pregnant women, about 6 will have a stillbirth. This means 9,994 won’t have a stillbirth. In comparison, at 42 weeks, out of 10,000 pregnant, about 10 will have a stillbirth. This means 9,990 won’t have a stillbirth. Here is a picture to give you an idea of what this means.” “So this means that an extra 4 women out of 10,000 might avoid a stillbirth by being induced at 41 weeks. For the other 9,994 women, it won’t make any difference.” Then circle/highlight the additional 4 to show the difference.

What do the guidelines say?

  • In an extensive evidence review from the U.S. Agency for Healthcare Research and Quality, researchers found that elective induction at 41 weeks decreases the risk of Cesarean and meconium aspiration syndrome, but that we’re not sure how this evidence translates into real-life settings. To read the free full text of this e-book, click here (Caughey et al. 2009).
  • The Ontario Midwives Association has a really comprehensive, easy-to-understand set of guidelines. To download the free PDF, click here.
  • To download the Society of Obstetricians and Gynaecologists of Canada guidelines (Canada), click here.
  • In 2014, ACOG released their latest recommendations on post-term pregnancy. Although their guidelines are not freely available to the public, ACOG recommends that induction of labor should take place between 42 weeks 0 days and 42 weeks 6 days, and that induction at 41 weeks can also be considered. If a woman planning a VBAC goes post-term, this does not mean she has to have a repeat Cesarean.

What’s the bottom line?

The whole topic of due dates and induction for due dates can be very confusing. There is a lot of information to digest. We feel that the most important points can be summarized like this:

Due dates:

  • The traditional way of calculating the estimated due date (40 weeks after the last menstrual period) is not evidence-based. Instead, it is more accurate to give women a range of time that they will probably give birth:
    • About half of first-time moms will give birth by 40 weeks and 5 days after the LMP, with the other half giving birth after that time point
    • About half of moms who have given birth before will give birth by 40 weeks and 3 days after the LMP, with the other half giving birth after that
  • An ultrasound before 20 weeks is usually more accurate than using the last menstrual period, and the accuracy of an ultrasound is highest if it is done between 11 and 14 weeks.
With her first pregnancy, Cristen favored the option of a physiologic birth.  When her nurse-midwife pressured her to have an induction in her 41st week, Cristen switched practices. "My resistance to having an induction at that point was a natural response to feeling strong-armed to have this major medical procedure based on no information other than 'This is what we like to do.'"  Cristen found a new care provider and went into labor on her own the very next day--at exactly 42 weeks.
With her first pregnancy, Cristen favored the option of a physiologic birth.  When her nurse-midwife pressured her to have an induction in her 41st week, Cristen switched practices. “My resistance to having an induction at that point was a natural response to feeling strong-armed to have this major medical procedure based on no information other than ‘This is what we like to do.’”  Cristen found a new care provider and went into labor on her own the very next day–at exactly 42 weeks.

Risks of going past 41 or 42 weeks:

  • There is a rise in the relative risk of stillbirth starting at about 39 weeks, depending on which study you are looking at. However, the overall risk is still low up until 42 weeks. At 42 weeks, the risk of stillbirth rises to about 1 in 1,000 in babies who are not growth-restricted. The risk may be higher in some women who have additional risk factors for stillbirth.
  • Women who experience post-term pregnancy (past 42 weeks) are more likely to experience infections and Cesareans, and their infants are more likely to experience meconium aspiration syndrome, NICU admissions, and low Apgar scores.

Induction

  • There is no clear right or wrong path with regard to induction at 41 or 42 weeks.
  • The lowest C-section rates happen in women who go into labor on their own. The next-lowest C-section rates happen in women who are induced for being late term or post-term. The highest C-section rates happen in women who choose to wait for spontaneous labor but end up having an induction later on.
  • Elective induction at 41 or 42 weeks may decrease the risk of stillbirth or newborn death. It is thought that there would need to be at least 328-410 inductions in order to prevent one stillbirth or newborn death.
  • Women should talk with their care provider about the pros and cons of waiting for spontaneous labor or induction at 41 and 42 weeks. This conversation should take into account the mother’s preferences, goals, values, personal birth history, chances of a successful induction (how “ripe” the cervix is, also known as the Bishop score”), and alternatives.

Final Thoughts

It’s important to note that basically none of this research evidence looked closely at women’s experiences or preferences. These non-medical factors are very real when it comes to individual decision-making. For example, it may be very important to a healthy first-time mother who very much wants an unmedicated birth to have a spontaneous labor, while it may be very important to a woman who has experienced miscarriages or stillbirth in the past to lower the absolute risk of stillbirth by any means necessary. All of these experiences and preferences are valid.

Evidence Based Birth® Resources on Big Babies


Click Here to Download a FREE Handout Sheet for this article

Get the printer-friendly PDF version of this article, here.

Get the printer-friendly PDF + a recorded Q&A, here!

Or save nearly 60% when you purchase the bundle of all of our top rated Evidence Based Birth® PDFs articles at once, here!

Become a professional member, and get immediate access to a continuing education course on Due Dates and Advanced Maternal Age ( 0.3 ACNM CEUs ), ALL of our printer-friendly PDFs, and more! For more information on how to become a monthly or annual member, click here.

Purchase our “due dates” buttons here! We also have an Evidence Based Birth® lanyard and flash drive that includes all the due dates handouts here.


Acknowledgments

I would like to extend my deepest gratitude to Sonja Billes, PhD, and Robert Modugno, MD, MBA, FACOG, who traveled to Lexington, Kentucky in 2014 to help me conduct the extensive literature search for this article. I would also like to thank my expert reviewers—Shannon J. Voogt, MD, Board-Certified in Family Medicine; Tara Elrod, CDM of Integrated Women’s Wellness in Alaska; Heather Thompson, MS, PhD, Research Director of Mountain Midwifery Center, and Deputy Director of Elephant Circle; Mimi Niles, CNM, MSN, MPH, and PhD student; and Cynthia B. Flynn, CNM, PhD, FACNM, Past President of the American Association of Birth Centers, expert midwife at www.pregnancy.org and founder of Birth Center Consulting. I would also like to thank Cristen Pascucci and Sharon Muza CD(DONA), BDT(DONA), LCCE, FACCE for their medical editing assistance.

 

Want to read an interview with the author about this article?

Visit Science and Sensibility here to read an interview with Rebecca Dekker, PhD, RN, APRN, about her findings in this article.


References:

American Congress of Obstetrics and Gynecology (2014). Committee opinion no 611: method for estimating due date. Obstet Gynecol 124(4): 863-866. Click here.

Ananth, C. V., S. Liu, et al. (2009). A comparison of foetal and infant mortality in the United States and Canada. Int J Epidemiol 38(2): 480-489. Click here for free full text.

Baskett, T. F. and F. Nagele (2000). Naegele’s rule: a reappraisal. BJOG 107(11): 1433-1435. Click here.

Boulvain, M., D. Faltin, et al. (2000). Prospective risk of stillbirth. Randomised trials of earlier induction of labour are needed. BMJ 320(7232): 445-446. Click here.

Buckley, Sarah J. (2015) Hormonal Physiology of Childbearing: Evidence and Implications for Women, Babies, and Maternity Care. Washington, D.C.: Childbirth Connection Programs, National Partnership for Women & Families, January 2015. Click here for free full text.

Caughey AB, et al. (2009). Maternal and Neonatal Outcomes of Elective Induction of Labor. Evidence Report/Technology Assessment No. 176. AHRQ Publication No. 09-E005. Rockville, MD.: Agency for Healthcare Research and Quality. March 2009. Click here for free full text.

Caughey, A. B. (2007). Measuring perinatal complications: methodologic issues related to gestational age. BMC Pregnancy Childbirth 7: 18. Click here.

Caughey, A. B. and T. J. Musci (2004). Complications of term pregnancies beyond 37 weeks of gestation. Obstet Gynecol 103(1): 57-62. Click here.

Caughey, A. B., N. E. Stotland, et al. (2003). What is the best measure of maternal complications of term pregnancy: ongoing pregnancies or pregnancies delivered? Am J Obstet Gynecol 189(4): 1047-1052. Click here.

Cotzias, C. S., S. Paterson-Brown, et al. (1999). Prospective risk of unexplained stillbirth in singleton pregnancies at term: population based analysis. BMJ 319(7205): 287-288. Click here for free full text.

Declercq, E. R., C. Sakala, et al. (2014). Major Survey Findings of Listening to Mothers(SM) III: Pregnancy and Birth: Report of the Third National U.S. Survey of Women’s Childbearing Experiences. J Perinat Educ 23(1): 9-16. Click here for free full text.

Divon, M. Y., A. Ferber, et al. (2002). Male gender predisposes to prolongation of pregnancy. Am J Obstet Gynecol 187(4): 1081-1083. Click here.

Divon, M. Y., A. Ferber, et al. (2004). A functional definition of prolonged pregnancy based on daily fetal and neonatal mortality rates. Ultrasound Obstet Gynecol 23(5): 423-426. Click here for free full text.

Fagerlin, A., Zikmund-Fisher, B. J., & Ubel, P. A. (2011). Helping patients decide: Ten steps to better risk communication. J Natl Cancer Inst 103(19): 1436-1443. Click here for free full text.

Feldman, G. B. (1992). Prospective risk of stillbirth. Obstet Gynecol 79(4): 547-553. Click here.

Flenady, V., L. Koopmans, et al. (2011). Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis. Lancet 377(9774): 1331-1340. Click here.

Gulmezoglu, A. M., C. A. Crowther, et al. (2012). Induction of labour for improving birth outcomes for women at or beyond term. Cochrane Database Syst Rev 6: CD004945. Click here for free full text.

Halloran, D. R., Y. W. Cheng, et al. (2012). Effect of maternal weight on postterm delivery. J Perinatol 32(2): 85-90. Click here.

Hannah, M. E., W. J. Hannah, et al. (1992). Induction of labor as compared with serial antenatal monitoring in post-term pregnancy. A randomized controlled trial. The Canadian Multicenter Post-term Pregnancy Trial Group. N Engl J Med 326(24): 1587-1592. Click here for free full text.

Hannah, M. E., C. Huh, et al. (1996). Postterm pregnancy: putting the merits of a policy of induction of labor into perspective. Birth 23(1): 13-19. Click here.

Hilder, L., K. Costeloe, et al. (1998). Prolonged pregnancy: evaluating gestation-specific risks of fetal and infant mortality. Br J Obstet Gynaecol 105(2): 169-173. Click here.

Hilder, L., K. Costeloe, et al. (2000). Prospective risk of stillbirth. Study’s results are flawed by reliance on cumulative prospective risk. BMJ 320(7232): 444-445; author reply 446. Click here for free full text.

Huang, D. Y., R. H. Usher, et al. (2000). Determinants of unexplained antepartum fetal deaths. Obstet Gynecol 95(2): 215-221. Click here.

Hussain, A. A., M. Y. Yakoob, et al. (2011). Elective induction for pregnancies at or beyond 41 weeks of gestation and its impact on stillbirths: a systematic review with meta-analysis. BMC Public Health 11 Suppl 3: S5. Click here for free full text.

Johnsen, S. L., T. Wilsgaard, et al. (2008). Fetal size in the second trimester is associated with the duration of pregnancy, small fetuses having longer pregnancies. BMC Pregnancy Childbirth 8: 25. Click here for free full text.

Jukic, A. M., D. D. Baird, et al. (2013). Length of human pregnancy and contributors to its natural variation. Hum Reprod 28(10): 2848-2855. Click here for free full text.

Khambalia, A. Z., C. L. Roberts, et al. (2013). Predicting date of birth and examining the best time to date a pregnancy. Int J Gynaecol Obstet 123(2): 105-109. Click here.

Kramer, M. S., S. Liu, et al. (2002). Analysis of perinatal mortality and its components: time for a change? Am J Epidemiol 156(6): 493-497. Click here for free full text.

MacDorman, M. F. and S. Kirmeyer (2009). Fetal and perinatal mortality, United States, 2005. Natl Vital Stat Rep 57(8): 1-19. Click here.

Margerison-Zilko, C. E., J. M. Goodman, et al. (2015). Post-term birth as a response to environmental stress : The case of September 11, 2001. Evol Med Public Health 2015(1): 13-20. Click here.

Menticoglou, S. M., & Hall, P. F. (2002). Routine induction of labour at 41 weeks gestation: nonsensus consensus. Br J Obstet Gynaecol 109: 485–491. Click here.

Mishanina, E., E. Rogozinska, et al. (2014). Use of labour induction and risk of cesarean delivery: a systematic review and meta-analysis. CMAJ 186(9): 665-673. Click here for free full text.

Mogren, I., H. Stenlund, et al. (1999). Recurrence of prolonged pregnancy. Int J Epidemiol 28(2): 253-257. Click here for free full text.

Morken, N. H., K. Klungsoyr, et al. (2014). Perinatal mortality by gestational week and size at birth in singleton pregnancies at and beyond term: a nationwide population-based cohort study. BMC Pregnancy Childbirth 14: 172. Click here for free full text.

NICE (2008). Induction of Labor: Clinical Guidelines, No. 70. National Collaborating Centre for Women’s and Children’s Health (UK). London: RCOG Press. Click here for free full text.

Oberg, A. S., T. Frisell, et al. (2013). Maternal and fetal genetic contributions to postterm birth: familial clustering in a population-based sample of 475,429 Swedish births. Am J Epidemiol 177(6): 531-537. Click here for free full text.

Olesen, A. W., O. Basso, et al. (1999). An estimate of the tendency to repeat postterm delivery. Epidemiology 10(4): 468-469. Click here.

Olesen, A. W., J. G. Westergaard, et al. (2003). Perinatal and maternal complications related to postterm delivery: a national register-based study, 1978-1993. Am J Obstet Gynecol 189(1): 222-227. Click here.

Palatnik, A. and W. A. Grobman (2015). Induction of labor versus expectant management for women with a prior cesarean delivery. Am J Obstet Gynecol 212(3): 358 e351-356. Click here.

Perneger, T. V. & Agoritsas, T. (2011). Doctors and patients’ susceptibility to framing bias: a randomized trial. J Gen Intern Med 26(12): 1411-1417. Click here for the free full text.

Rosenstein, M. G., Y. W. Cheng, et al. (2012). Risk of stillbirth and infant death stratified by gestational age. Obstet Gynecol 120(1): 76-82. Click here for free full text.

Sanchez-Ramos, L., F. Olivier, et al. (2003). Labor induction versus expectant management for postterm pregnancies: a systematic review with meta-analysis. Obstet Gynecol 101(6): 1312-1318. Click here.

Savitz, D. A., J. W. Terry, Jr., et al. (2002). Comparison of pregnancy dating by last menstrual period, ultrasound scanning, and their combination. Am J Obstet Gynecol 187(6): 1660-1666. Click here.

Smith, G. C. (2001). Life-table analysis of the risk of perinatal death at term and post term in singleton pregnancies. Am J Obstet Gynecol 184(3): 489-496. Click here.

Smith, G. C. (2001). Use of time to event analysis to estimate the normal duration of human pregnancy. Hum Reprod 16(7): 1497-1500. Click here for free full text.

Spong, C. Y. (2013). Defining “term” pregnancy: recommendations from the Defining “Term” Pregnancy Workgroup. JAMA 309(23): 2445-2446. Click here.

Stillbirth Collaborative (2011). Association between stillbirth and risk factors known at pregnancy confirmation. JAMA 306(22): 2469-2479. Click here for free full text.

Taipale, P. and V. Hiilesmaa (2001). Predicting delivery date by ultrasound and last menstrual period in early gestation. Obstet Gynecol 97(2): 189-194. Click here.

Warland, J. and E. A. Mitchell (2014). A triple risk model for unexplained late stillbirth. BMC Pregnancy Childbirth 14: 142. Click here for free full text.

Weiss, E., K. Krombholz, et al. (2014). Fetal mortality at and beyond term in singleton pregnancies in Baden-Wuerttemberg/Germany 2004-2009. Arch Gynecol Obstet 289(1): 79-84. Click here for free full text.

Wennerholm, U. B., H. Hagberg, et al. (2009). Induction of labor versus expectant management for post-date pregnancy: is there sufficient evidence for a change in clinical practice? Acta Obstet Gynecol Scand 88(1): 6-17. Click here.

Wood, S., S. Cooper, et al. (2014). Does induction of labour increase the risk of caesarean section? A systematic review and meta-analysis of trials in women with intact membranes. BJOG 121(6): 674-685; discussion 685. Click here for free full text.

Yeast et al. (1999). Induction of labor and the relationship to cesarean delivery: A review of 7001 consecutive inductions. Am J Obstet Gynecol 180:628-33. Click here.

Yudkin, P. L., L. Wood, et al. (1987). Risk of unexplained stillbirth at different gestational ages. Lancet 1(8543): 1192-1194. Click here.

 

This entry was posted in Uncategorized. Bookmark the permalink.

Leave a Reply